Abstract—The article is devoted to the comparison of laboratory methods for measuring the concentration of gases in the air and methods using compact sensors mounted on an Unmanned Aerial Vehicle (UAV). Among the gases studied are carbon dioxide and carbon monoxide, sulfur dioxide, and nitrogen oxide. The description of the tested sensors (Gas analyser GANK-4, aspirator PU-4E, spectrophotometer PE-5400VI, Libelium Waspmote Gas Sensors PRO), measurement methods and equipment for the flight mission are presented. Special attention is paid to the influence of meteorological parameters on the measured concentration. Finally, measurement results are compared with the recommended indices of the content of the investigated gases.